Cholesterol is one of the most well-studied lipid moieties. It's the part of membrane as it contains 15%-30% of cellular membranes and it is also transported into cells by LDL and HDL, which bind to corresponding receptors. So cholesterol-siRNA can bind to LDL and HDL effectively. Cholesterol was conjugated to the 3′-terminus of the sense strand of siRNA via a pyrrolidone linkage. So cholesterol-siRNA conjugate can dramatically improve the pharmacokinetic properties of siRNA, like half-life and bioavailability in serum. We provide cholesterol-siRNA conjugates with high quality. We can design and synthesis the siRNA based on the target gene, and our parent company BOC Sciences can provide high quality cholesterol, we can conjugate them to form cholesterol-siRNA conjugates.
