Cell migration is a fundamental process that involves the translation of cells from one location to another by adopting different motility modes, such as mesenchymal, amoeboid, or collective migration. Cell migration is essential for the development and maintenance of multicellular organisms. It also plays a key role in cell migration-mediated tissue organization, organogenesis, and homeostasis, especially in the immune response and cancer spreading which are the hotspots of clinical studies recently.