Microbes in nature always use various protection mechanisms that enable them to coexist with harsh environments and invasive nucleic acids. Many microbes can resist nucleic acid invasion through specific methods based on gene sequence. CRISPR/Cas9 is one of these protection mechanisms and the most widely used genome editing technology. Creative Biogene provides the CRISPR/Cas9 method for microbial genome editing services (including gene knockout, site-directed mutation, site-directed insertion of foreign sequences, etc.). Compared with traditional gene knockout methods, this method is more convenient for subsequent experimental research.