The light-controllable PROTAC combines the concept of proteolysis targeting chimeric (PROTAC) and photochemistry that is called photopharmacology, which is an emerging field that uses light to precisely control drug activity in spatial and temporal resolution. PROTAC is a promising technology to target intracellular proteins including undruggable proteins targets for degradation. A PROTAC molecule is composed of three essential components as follows: a target protein binding ligand, a ligand of the E3 ligase, and a suitable linker that ensures the correct orientation of and the distance between the two ligands.
