Proteins can perform a series of significant functions with only 20 natural amino acids. These natural amino acids carry a limited number of functional groups, restricting the function of proteins in chemical and biological science research and applications. Structure modification of proteins through chemical modification, genetic site-directed mutation, and computer-aided protein design has given new functions to natural proteins but is still limited to natural amino acids. Unnatural Amino Acids, which artificially impart diverse functional groups, are prominent in protein modification. These non-natural amino acids contain keto, aldehyde, azide, alkynyl, alkenyl, amido, nitro, phosphate, sulfonate, and other functional groups, and can also be modified. Modifying unnatural amino acids of proteins brings new opportunities for theoretical research and applications. BOC Sciences can synthesize more than 2000 amino acid derivatives, of which our customers can request customization.
Asymmetric synthesis of amino acids is an important part of the custom synthesis of amino acids. The methods mainly include resolution, high homologation of L-amino acids, asymmetric alkylation, asymmetric alkylation of imines, and asymmetric hydrogenation of dehydrogenated amino acids. Asymmetric amino acid synthesis methods are diverse and unique. Different synthesis methods can often complement each other. For example, asymmetric catalytic hydrogenation for the synthesis of chiral α-amino acids has a high yield, high enantioselectivity, atomic economy, and environmental friendliness. Chiral adjuvant-induced alkylation methods can efficiently synthesize quaternary amino acids.
BOC Sciences is committed to providing a variety of synthetic amino acids to help with our customers’ research. We are fully equipped to meet the needs of customers.
