Type Brauer-Buschke-FischerPatient with type 1 diabetes mellitusHyperkeratosis can occur as an isolated symptom or as part of other skin diseases or genetic defects.Reactive hyperkeratosis can be caused, for example, by
Hyperkeratosis due to increased mechanical strain is called callus. The common wart (verruca vulgaris) is an example of a hyperkeratosis caused by infection.Examples of diseases that are endogenous causes of hyperkeratosis include: