Pustules on the abdominal skin of the calf because of vaccination for the production of smallpox-vaccines.In 1796 the English physician Edward Jenner (1749-1823) discovered the active immunization: The boy, whom he had been vaccinated with harmless cowpox, was six weeks later protected against infection with human smallpox.Smallpox is caused by a viral infection that is characterized by typical skin lesions. They are highly contagious and therefore were in the past the cause of many epidemics. Because of a worldwide vaccination prophylaxis the world is according to WHO smallpox-free since 1980.Moulage / Wax / teaching materials DHMD / 1907-1923Source: Deutsches Hygiene Museum in Dresden