Herpes simplex is a sexually transmitted disease. The viral agent (HSV-2) resides in the regional sacral ganglions (S1 S2 S3) and can be reactivated. The viral shedding can occur with and without symptoms at different anatomical sites as the vulva, the cervix and the perianal region. Antiviral treatment (aciclovir, valaciclovir) should be administered to reduce symptoms and occasions of recurrence